We are interested in addressing fundamental questions in chromatin biology and regulation of gene expression, focusing on the mechanism of distal regulation of gene expression and how mutations at regulatory elements lead to disease, with focus on role of histone modifications, enhancers, and noncoding transcription. Current project in the chromatin and gene regulation lab include the investigation of the role of histone H3 globular acetylations (H3K122ac and H3K64ac), H4 tail acetylation (H4K16ac) and transcriptional coactivators including acetyl binding protein - BRD4 in enhancer function.


Group Leader

Postdoctoral Fellows


Dr. Debosree Pal (starting in October 2019)

Vacancy for Bioinformatics Postdoctoral fellow

Vacancy for experimental Postdoctoral fellow

Visiting Fellows/Students

Razvan Minca

PhD students

Please write to p.m.madapura@qmul.ac.uk if you are interested

MSc students

Past members

Dr. Myles Garstang

Jimmy Mathaikunju

Laurène Salesse

Deborah Abban-Mensah

Sophie Shi

Karabo Marole

Valentine Brugerolle

Dr. Tahir Khan


Cornelia de Lange Syndrome is a multisystem developmental disorder typically caused by mutations in the gene encoding the cohesin …

The genetic aetiology of a large proportion of intellectual disability (ID) cases still remains undiagnosed as de novo mutations (DNMs) …

We found that the clinical phenotype associated with BRD4 haploinsufficiency overlapped with that of Cornelia de Lange syndrome (CdLS), …

Long noncoding RNAs (lncRNAs) have been implicated in various biological functions including regulation of gene expression. However, …

Histone acetylation is generally associated with active chromatin, but most studies have focused on the acetylation of histone tails. …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in mammalian cells. Yet, H4K16 acetylation is …

Increasing evidence suggests that chromatin modifications have important roles in modulating constitutive or alternative splicing. Here …